Why the study?
Does selective inhibition of phosphodiesterase subtypes enhance prostaglandin E2-induced relaxation in isolated pulmonary arteries of newborn lambs?
Does selective inhibition of phosphodiesterase subtypes enhance prostaglandin E2-induced relaxation in isolated pulmonary arteries of newborn lambs?
PDE3 and PDE4 are the primary enzymes hydrolyzing cAMP in newborn lamb pulmonary arteries, and their combined inhibition synergistically enhances PGE2-induced vasorelaxation.
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May warrant investigation of dual PDE3/4 inhibition in neonatal pulmonary hypertension; leaves open human translation.
Gao et al. (1998) studied this question.
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