Why the study?
Do Prostaglandins E2 and I2 cause different relaxations in pulmonary veins compared to pulmonary arteries in newborn lambs?
Do Prostaglandins E2 and I2 cause different relaxations in pulmonary veins compared to pulmonary arteries in newborn lambs?
PGE2 and PGI2 are more potent vasodilators in pulmonary veins than in arteries in newborn lambs, with PGE2 playing a more important role in modulating pulmonary vascular tone.
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Hypothesis-generating for differential prostaglandin effects on neonatal pulmonary veins; human studies needed before any clinical relevance.
Gao et al. (1996) studied this question.
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