Why the study?
Does E4021 dilate the pulmonary circulation in fetal and newborn lambs with persistent pulmonary hypertension?
Population
Control late-gestation fetal lambs and newborn lambs with persistent pulmonary hypertension after prenatal…
Design
Preclinical
Authors
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E4021 merits evaluation as a selective pulmonary vasodilator in PPHN; leaves open translation from this lamb model to human neonates.
Does E4021 dilate the pulmonary circulation in fetal and newborn lambs with persistent pulmonary hypertension?
The phosphodiesterase inhibitor E4021 selectively dilates the pulmonary circulation and decreases pulmonary vascular resistance in a lamb model of persistent pulmonary hypertension.
Dukarm et al. (1999) studied this question.
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