January 1, 1996Journal of Clinical InvestigationOpen Access

Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.

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Population

Chronically hypoxic rats (pulmonary hypertensive) and normotensive control rats

Comparison

E4021 administered in vitro and intravenously vs Normotensive control rats and inhaled nitric oxide

Design

Preclinical

Authors

ACA.H. CohenTulane University KHKimberly A. HansonUniversity of Washington KMK G MorrisBasingstoke and North Hampshire Hospital

Discussion

Member takes

Implication

Supports selective pulmonary vasodilation by PDE5 inhibition in rat PH models; leaves open clinical translation.

Structured PICO

Population

Chronically hypoxic rats (pulmonary hypertensive) and normotensive control rats

Intervention

E4021 (cGMP-specific PDE5 inhibitor) administered in vitro and intravenously

Comparator

Normotensive control rats (for baseline comparisons) and inhaled nitric oxide

Outcome

Hypoxic vasoconstriction, pulmonary artery pressure, and total pulmonary resistancesurrogate

Inhibition of cGMP-specific PDE5 with E4021 selectively and effectively vasodilates the pulmonary circulation in chronically hypoxic rats, comparable to inhaled nitric oxide.

Cite This Study

Cohen et al. (1996) studied this question.

synapsesocial.com/papers/6a78c3c62e130d02afed4d7d https://doi.org/10.1172/jci118386

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Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider