Lung cGMP release subsequent to NO inhalation in pulmonary hypertension: respondersversusnonresponders
Why the study?
Does the magnitude of NO-induced cGMP release correlate with pulmonary vascular resistance reduction in patients with severe precapillary pulmonary hypertension?
Population
20 patients with severe precapillary pulmonary hypertension (PH)
Design
Cohort
Authors
Discussion
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Member takes
Implication
NO-induced cGMP rise does not predict hemodynamic response in precapillary PH; leaves open cGMP as a biomarker for vasodilator testing.
Structured PICO
Does the magnitude of NO-induced cGMP release correlate with pulmonary vascular resistance reduction in patients with severe precapillary pulmonary hypertension?
P
Population
20 patients with severe precapillary pulmonary hypertension (PH)
I
Intervention
Nitric oxide (NO) inhalation during Swan-Ganz catheterization
O
Outcome
Pulmonary vascular resistance (PVR) response (decrease >20%) and plasma cyclic guanosine monophosphate (cGMP) and atrial natriuretic peptide (ANP) levelssurrogate
In patients with severe precapillary pulmonary hypertension, NO inhalation provokes a prompt increase in cGMP secretion, but the magnitude of this release does not predict the haemodynamic response.
Cite This Study
Ghofrani et al. (2002) studied this question.