Why the study?
Does EDRF inhibition or L-arginine supplementation alter pulmonary arterial pressure in newborn lambs with induced pulmonary hypertension?
Population
8 newborn lambs with pulmonary hypertension induced by intravenous infusion of U-46619 or hypoxia
Comparison
Pretreatment with N omega-nitro-L-arginine or… vs Responses to U-46619 or hypoxia without…
Design
Preclinical
Authors
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EDRF limits pulmonary hypertension in newborn lambs; hypothesis-generating for L-arginine in human neonates with PPHN.
Does EDRF inhibition or L-arginine supplementation alter pulmonary arterial pressure in newborn lambs with induced pulmonary hypertension?
In a newborn lamb model, EDRF release limits the increase in pulmonary arterial pressure during pulmonary hypertension, with L-arginine availability being rate-limiting for its synthesis.
Fineman et al. (1992) studied this question.
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