Population
Lungs and conduit pulmonary arteries isolated from control and chronically hypoxic (hypertensive) rats
Comparison
N omega-nitro-L-arginine, an inhibitor of EDRF… vs Normotensive lungs and conduit pulmonary arteries
Design
Preclinical
Authors
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Basal EDRF may suppress vasoconstrictor tone in hypertensive pulmonary vessels; leaves open relevance to human pulmonary hypertension.
In hypertensive rat pulmonary arteries, basal release of EDRF suppresses vasoconstrictor mechanisms that are not expressed in normotensive arteries.
Oka et al. (1993) studied this question.
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