Why the study?
Does administration of sulfaphenazole, phenylbutazone, or oxyphenbutazone inhibit tolbutamide metabolism?
Population
Subjects receiving tolbutamide (n=12)
Comparison
Sulfaphenazole, phenylbutazone, or oxyphenbutazone vs Baseline tolbutamide elimination
Design
Other
Authors
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May increase hypoglycemia risk during tolbutamide coadministration; leaves open mechanistic distinctions between direct CYP inhibition and low-activity P450 induction.
Does administration of sulfaphenazole, phenylbutazone, or oxyphenbutazone inhibit tolbutamide metabolism?
Sulfaphenazole directly inhibits tolbutamide metabolism, whereas phenylbutazone and oxyphenbutazone likely induce a low-activity form of cytochrome P-450.
Pond et al. (1977) studied this question.
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