Key result
Two-dimensional tissue Doppler imaging measured significantly higher radial strain in the subendocardium (106.4%) compared to the subepicardium (54.2%; p<0.003) in young healthy humans.
Why the study?
Is it feasible to measure radial deformation in multiple myocardial layers using 2-dimensional tissue Doppler imaging in young, healthy humans?
Observational (n=23)
Is it feasible to measure radial deformation in multiple myocardial layers using 2-dimensional tissue Doppler imaging in young, healthy humans?
Absolute Event Rate: 106.4% vs 54.2%
p-value: p=<0.003
It is feasible to measure radial velocity, strain rate, and strain in up to three individual myocardial layers using tissue Doppler imaging in healthy humans.
Feasible to assess layer-specific radial strain by 2D tissue Doppler in healthy hearts; leaves open clinical utility and validation in disease.
Objectives. Measuring strain in multiple myocardial layers using 2-dimensional tissue Doppler imaging may provide valuable diagnostic information about non-transmural disease. However, its feasibility in humans has not been demonstrated previously, and optimal machine settings not defined. Design. From parasternal short axis, zoomed tissue Doppler imaging of the left ventricular inferior wall was obtained in 23 young, healthy humans. Images were recorded with six different machine settings. Velocity, strain rate and strain were measured in two and three layers across the wall. Result. For two-layer-measurements, all subendocardial values were significantly higher than the subepicardial ones (p<0.003 for all data sets). Minimal radial and maximal lateral averaging resulted in largest strain differences: 106.4±32.6% (mean±SD) subendocardially versus 54.2±20.1% subepicardially. By similar settings in three layers, strain was 105.7±34.5% subendocardially, 81.2±26.9% midmyocardially and 48.3±26.9% subepicardially (p <0.05). Conclusion. We have demonstrated that it is feasible to measure radial velocity, strain rate and strain in up to three individual layers in young healthy humans, and the diagnostic potentials should be tested on patient groups.
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Davidsen et al. (2010) conducted an observational in Healthy (n=23). 2-dimensional tissue Doppler imaging vs. Subepicardial layer (vs subendocardial layer) was evaluated on Radial strain (p=<0.003). Two-dimensional tissue Doppler imaging measured significantly higher radial strain in the subendocardium (106.4%) compared to the subepicardium (54.2%; p<0.003) in young healthy humans.
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