Key result
Grade I diastolic dysfunction in controlled hypertension is linked to impaired cardiac sympathetic innervation on 123I-MIBG.
Why the study?
The role of sympathetic dysfunction in the pathophysiology of diastolic dysfunction without heart failure among patients with hypertension controlled with ACE inhibitors or ARBs was unknown.
Observational
Cardiac sympathetic nervous system dysfunction correlates with left ventricular hypertrophy and diastolic dysfunction in patients with controlled hypertension.
Answers are grounded in this paper and cite their sources.
May support sympathetic imaging evaluation in controlled hypertension with diastolic dysfunction; leaves open clinical utility of 123I-MIBG parameters.
eertechzhypertension compared to normal blood pressure, and positively correlates with left ventricular muscle mass index and wall thickness [3,4].Cardiac autonomic dysfunction plays a pivotal role in the pathogenesis of heart failure with reduced left ventricular ejection fraction.Angiotensin II and α1-adrenergic receptor agonist also induce myocardial hypertrophy and diastolic dysfunction in animal models [5].The role of sympathetic dysfunction in the pathophysiology of diastolic dysfunction without heart failure among subjects treated with angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) is unknown.Among subjects with hypertension controlled with ACE inhibitors or ARBs, our hypothesis suggests a lower 123 I-MIBG uptake and H/M ratio, and a higher washout rate (WOR) in cases with grade I diastolic dysfunction compared to cases with normal diastolic function.
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Elsayed Abo‐Salem (2016) conducted an observational in Controlled hypertension and diastolic left ventricular dysfunction. Grade I diastolic left ventricular dysfunction vs. Normal diastolic function was evaluated on 123I-MIBG uptake, heart-to-mediastinum (H/M) ratio, and washout rate (WOR). Grade I diastolic dysfunction in controlled hypertension is hypothesized to be associated with lower 123I-MIBG uptake and H/M ratio and higher washout rate compared to normal diastolic function.
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