Key result
Essential hypertension with altered left ventricular geometry, particularly concentric and eccentric hypertrophy, was associated with greater impairment of cardiac diastolic function than controls.
Why the study?
How does left ventricular diastolic function vary among hypertensive patients with different left ventricular geometric patterns compared to normal controls?
Observational (n=162)
How does left ventricular diastolic function vary among hypertensive patients with different left ventricular geometric patterns compared to normal controls?
Left ventricular diastolic dysfunction in hypertensive patients worsens progressively with the development of abnormal left ventricular geometric patterns, particularly concentric and eccentric hypertrophy.
Supports closer diastolic assessment in hypertensives with hypertrophy; hypothesis-generating and requires prospective validation before practice change.
To evaluate the alteration of cardiac function in hypertensive patients with different left ventricular geometric patterns. Echocardiography was used to study left ventricular geometry and cardiac diastolic function in 117 cases of essential hypertension, with 45 normal cases as controls. Echocardiographic date were used to calculated the left ventricular mass index (LVMI) and relative wall thickness (RWT), which values in turn were used to divide the subjects into four groups. The left atrial dimension of the group, with the exception of these hypertensives who showed normal geometry, was larger than that of the control group. The damage of peak of E velocity, peak of A velocity, E/A and the slope between the E and F points (E to F slope) were greater than in hypertension than in the control group. The concentric hypertrophy group and eccentric hypertrophy group suffered more serious damage of left ventricular diastolic function than the concentric remodeling group, and damage of left ventricular diastolic function in the concentric remodeling group was greater than that in the normal geometry group. The degree of cardiac diastolic function damage differed among patients with different left ventricular geometric patterns, when the cardiac structure was changed, the degree of cardiac diastolic function damage increased.
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Qu et al. (2001) conducted an observational in Essential hypertension (n=162). Essential hypertension with different left ventricular geometric patterns vs. Normal controls was evaluated on Cardiac diastolic function (peak E velocity, peak A velocity, E/A, and E to F slope). Essential hypertension with altered left ventricular geometry, particularly concentric and eccentric hypertrophy, was associated with greater impairment of cardiac diastolic function than controls.
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