Why the study?
Does molsidomine prevent pulmonary hypertension and vascular remodeling in a rat model of monocrotaline-induced pulmonary hypertension?
Population
Sprague-Dawley rats
Comparison
Monocrotaline 80 mg/kg single subcutaneous… vs Normal saline (control) and MCT alone
Design
Preclinical
Follow-up
2 weeks
Authors
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Hypothesis-generating for NO prodrugs in experimental PH; leaves open translation to human disease.
Does molsidomine prevent pulmonary hypertension and vascular remodeling in a rat model of monocrotaline-induced pulmonary hypertension?
Continuous infusion of the nitric oxide prodrug molsidomine prevents the development of pulmonary hypertension and right ventricular hypertrophy in a monocrotaline-induced rat model.
Mathew et al. (1997) studied this question.
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