Why the study?
Does monocrotaline-induced pulmonary hypertension impair endothelium-dependent relaxation via decreased NO production and altered Ca2+ metabolism in rats?
Population
6-week-old male Sprague Dawley rats (180-210 g), n=104
Comparison
Monocrotaline 60 mg/kg single subcutaneous… vs Vehicle (single subcutaneous injection)
Design
Preclinical
Follow-up
21 days
Authors
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No immediate clinical implications; leaves open whether Ca2+-eNOS dissociation drives human pulmonary hypertension.
Does monocrotaline-induced pulmonary hypertension impair endothelium-dependent relaxation via decreased NO production and altered Ca2+ metabolism in rats?
Impaired endothelium-dependent relaxation in MCT-induced pulmonary hypertension is caused by a dissociation between eNOS expression and NO production, potentially due to altered calcium metabolism.
Nakazawa et al. (1999) studied this question.
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