December 2, 2011The Journal of Dermatology

Targeted overexpression of Angptl6/angiopoietin‐related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet B

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Population

Angptl6/AGF transgenic mice and wild-type littermates

Comparison

Acute or chronic ultraviolet (UV)-B exposure vs Wild-type littermates exposed to the same UV-B…

Design

Preclinical

Follow-up

14 weeks

Authors

HOHidenori OkazakiEhime Prefectural Central Hospital SHSatoshi HirakawaHamamatsu University MSMasachika ShudouEhime University

Discussion

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Implication

Angptl6/AGF overexpression may promote photoaging via angiogenesis; hypothesis-generating in mice and should not yet change practice.

Structured PICO

Population

Angptl6/AGF transgenic mice and wild-type littermates

Intervention

Acute or chronic ultraviolet (UV)-B exposure

Comparator

Wild-type littermates exposed to the same UV-B doses

Outcome

Skin alterations, angiogenesis, and lymphatic vessel enlargementsurrogate

Overexpression of Angptl6/AGF promotes UV-B-induced skin alterations in mice, highlighting angiogenesis as a potential target for preventing skin photo-aging.

Cite This Study

Okazaki et al. (2011) studied this question.

synapsesocial.com/papers/6a735d8755ee283707b87341 https://doi.org/10.1111/j.1346-8138.2011.01396.x

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Targeted overexpression of Angptl6/angiopoietin‐related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet B

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Targeted overexpression of Angptl6/angiopoietin‐related growth factor in the skin promotes angiogenesis and lymphatic vessel enlargement in response to ultraviolet B

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider