Key result
Ultraviolet radiation exposure significantly increased concentrations of Ang-2, VEGF, and TNFα in suction blister fluids from human skin and triggered Ang-2 release in vitro.
Population
Human skin and human dermal microvascular endothelial cells in vitro
Design
Preclinical
Authors
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UVR effects on skin microvasculature remain hypothesis-generating; clinical relevance and Ang-1 modulation require prospective validation before practice consideration.
UVR triggers the release of endothelial Ang-2, promoting destabilization and a pro-inflammatory phenotype of the microvascular endothelium, which can be counteracted by Ang-1.
Navid et al. (2011) studied UVR-induced erythema. Ultraviolet radiation (UVR) exposure was evaluated on Concentrations of Ang-2, VEGF, and TNFα. Ultraviolet radiation exposure significantly increased concentrations of Ang-2, VEGF, and TNFα in suction blister fluids from human skin and triggered Ang-2 release in vitro.
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