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Summarize the regulatory roles and ligand-binding mechanisms of villin in directing actin filament dynamics and epithelial cell behavior.

February 26, 2008FEBS LettersOpen Access

Regulation of cell structure and function by actin‐binding proteins: Villin's perspective

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Summarize the regulatory roles and ligand-binding mechanisms of villin in directing actin filament dynamics and epithelial cell behavior.
Synthesized findings from epithelial cell lines and villin knockout mouse models evaluating cell structure, migration, and survival.
Assessed biochemical interactions between villin and binding partners, including F-actin, G-actin, calcium, phospholipids, and phospholipase C-gamma1.
Villin modulates actin filament dynamics, cell morphology, epithelial-to-mesenchymal transition, cell migration, and cell survival.
Ligand binding to calcium, phospholipids, and phospholipase C-gamma1 mediates critical crosstalk between extracellular signaling cascades and intracellular actin reorganization.

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Implication

Mechanistic review demonstrates villin-mediated regulation of actin dynamics and morphology in epithelial cells, highlighting its essential role in signaling crosstalk and cell survival.

Cite This Study

Khurana et al. (2008) studied this question.

synapsesocial.com/papers/6a735db4668da3c6682c2b14 https://doi.org/10.1016/j.febslet.2008.02.040

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Implication

Mechanistic review demonstrates villin-mediated regulation of actin dynamics and morphology in epithelial cells, highlighting its essential role in signaling crosstalk and cell survival.

Regulation of cell structure and function by actin‐binding proteins: Villin's perspective

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Discussion

Implication

Cite This Study

Regulation of cell structure and function by actin‐binding proteins: Villin's perspective

Key Points

Discussion

Implication

Cite This Study

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