What question did this study set out to answer?

To evaluate and compare the effects of the probiotic Enterococcus faecium CRL183, an isoflavone mixture, and simvastatin on blood lipid profiles and aortic atherosclerotic lesion formation in hypercholesterolemic rabbits.

January 1, 2009Lipids in Health and DiseaseOpen Access

Effects of probiotic bacteria, isoflavones and simvastatin on lipid profile and atherosclerosis in cholesterol-fed rabbits: a randomized double-blind study

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To evaluate and compare the effects of the probiotic Enterococcus faecium CRL183, an isoflavone mixture, and simvastatin on blood lipid profiles and aortic atherosclerotic lesion formation in hypercholesterolemic rabbits.
Randomized double-blind study allocating 30 rabbits across five groups (n=6 per group) for 60 days: normocholesterolemic control, hypercholesterolemic diet (1.0% cholesterol wt/wt), and hypercholesterolemic diet supplemented with E. faecium, isoflavones, or simvastatin.
Serum total cholesterol, HDL-C, non-HDL-C, and triglycerides were quantified using enzymatic assays, and atherosclerosis was measured as the percentage of lesion area relative to total aortic area.
Simvastatin significantly reduced total cholesterol by 16% and non-HDL-C by 17% while increasing HDL-C by 98% compared to the untreated hypercholesterolemic group; E. faecium significantly raised HDL-C by 43.3% (P < 0.05).
Both E. faecium and simvastatin significantly lowered triglyceride levels relative to the hypercholesterolemic and isoflavone groups, while isoflavones produced non-significant 9% reductions in total cholesterol and non-HDL-C.
None of the treatments demonstrated a statistically significant reduction in aortic atherosclerotic lesion development across evaluated aortic segments (P > 0.05).

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Implication

Randomized double-blind trial shows Enterococcus faecium and simvastatin improve lipid profiles in hypercholesterolemic rabbits, indicating potential adjuvant benefits for cardiovascular risk.

Cite This Study

Cavallini et al. (2009) studied this question.

synapsesocial.com/papers/6a735dfff60b59e999b8729a https://doi.org/10.1186/1476-511x-8-1

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Implication

Randomized double-blind trial shows Enterococcus faecium and simvastatin improve lipid profiles in hypercholesterolemic rabbits, indicating potential adjuvant benefits for cardiovascular risk.

Effects of probiotic bacteria, isoflavones and simvastatin on lipid profile and atherosclerosis in cholesterol-fed rabbits: a randomized double-blind study

Key Points

Discussion

Implication

Cite This Study

Effects of probiotic bacteria, isoflavones and simvastatin on lipid profile and atherosclerosis in cholesterol-fed rabbits: a randomized double-blind study

Key Points

Discussion

Implication

Cite This Study

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