What type of study is this?

This is a Pre-Registered Trial study.

What question did this study set out to answer?

This study aims to evaluate the effects of probiotics on hypercholesterolemia and gut microbiota in rats on a high-fat diet.

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Probiotic supplementation lowers triglycerides in hypercholesterolemic rats, indicating benefits for liver function and gut microbiota.

This study aims to evaluate the effects of probiotics on hypercholesterolemia and gut microbiota in rats on a high-fat diet.
Rats were divided into five groups: normal diet, high-fat diet, high-fat diet + Rosuvastatin, high-fat diet + probiotics, and high-fat diet + Rosuvastatin + probiotics.
Probiotic Lactobacillus spp. was administered to assess its impact on weight, lipid profiles, and liver function.
Histological analysis and gut microbiota composition were evaluated post-intervention.
Probiotic treatment significantly reduced triglycerides, total cholesterol, and LDL-C levels compared to the high-fat diet group.
Probiotics improved liver enzymes ALT and AST levels, indicating better liver function.
Histological analysis showed reduced hepatocellular degeneration and lower pro-inflammatory cytokine levels, such as IL-1β.

Chriaa et al. (2026) studied this question.

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