Why the study?
Does genetic deletion of COX-2 prevent captopril-induced increases in renin expression in mice?
Population
Age-matched wild-type (+/+), heterozygotes (+/-), and homozygous null (-/-) mice for the COX-2 gene
Comparison
Captopril (ACE inhibitor) administered for 7 days vs Wild-type and heterozygote mice compared to…
Design
Preclinical
Follow-up
7 days
Authors
Loading...
Suggests COX-2 is required for captopril-stimulated renin in mice; leaves open whether COX-2 inhibition alters ACE inhibitor efficacy in patients.
Does genetic deletion of COX-2 prevent captopril-induced increases in renin expression in mice?
Genetic deletion of COX-2 prevents ACE inhibitor-mediated increases in renal renin production, demonstrating that macula densa COX-2 is a key mediator of the renin-angiotensin system.
Cheng et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: