Angiotensin II attenuates renal cortical cyclooxygenase-2 expression

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Population

Rats and mutant mice homozygous for Agtr1a and Agtr1b null mutations (Agtr1a-/-, Agtr1b-/-)

Comparison

Captopril, losartan, or captopril with/without… vs Control/untreated animals, or captopril alone…

Design

Preclinical

Follow-up

1 week (for captopril +/- SC58236 experiment)

Authors

Discussion

COX-2 may mediate renin response to ACE inhibition in rodents; hypothesis-generating and should not yet change practice.

Population

Rats and mutant mice homozygous for Agtr1a and Agtr1b null mutations (Agtr1a-/-, Agtr1b-/-)

Intervention

Captopril (ACE inhibitor), losartan (AT1 receptor antagonist), or captopril with/without SC58236 (specific COX-2 inhibitor)

Comparator

Control/untreated animals, or captopril alone versus captopril plus SC58236

Outcome

Renal cortical COX-2 mRNA and immunoreactivity expression, and plasma renin activitysurrogate

Angiotensin II inhibitors augment renal cortical COX-2 expression, which in turn mediates increased renin production in response to ACE inhibition.

Cheng et al. (1999) studied this question.

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