September 1, 1999Hypertension

Inhibition of the Renin-Angiotensin System Upregulates Cyclooxygenase-2 Expression in the Macula Densa

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Why the study?

Does inhibition of the renin-angiotensin system upregulate COX-2 expression in the macula densa in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats

Comparison

Ramipril, losartan, PD123319, low-salt diet, or… vs Control/baseline or single interventions…

Design

Preclinical

Follow-up

4 days

Authors

KWKonrad WolfMünchen Klinik HCHayo CastropCzech Academy of Sciences, Institute of Physiology AHAndrea HartnerUniversitätsklinikum Erlangen

Discussion

Member takes

Implication

No change to RAS inhibitor use in patients; hypothesis-generating for AT1-mediated COX-2 feedback in rodent kidney.

Structured PICO

Does inhibition of the renin-angiotensin system upregulate COX-2 expression in the macula densa in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats

Intervention

Ramipril (10 mg/kg per day), losartan (30 mg/kg per day), PD123319 (6 mg/kg per day), low-salt diet (0.02% wt/wt), or combination of low-salt diet with ramipril for 4 days

Comparator

Control/baseline (implied) or single interventions compared to combination

Outcome

Expression of COX-2 mRNA and protein (immunoreactivity) in the renal cortex/macula densasurrogate

Endogenous angiotensin II inhibits COX-2 expression in the macula densa via AT1 receptors, suggesting a novel indirect negative feedback control of the renin system.

Cite This Study

Wolf et al. (1999) studied this question.

synapsesocial.com/papers/6a856a7337bcb8373dada144 https://doi.org/10.1161/01.hyp.34.3.503

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Inhibition of the Renin-Angiotensin System Upregulates Cyclooxygenase-2 Expression in the Macula Densa

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of the Renin-Angiotensin System Upregulates Cyclooxygenase-2 Expression in the Macula Densa

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider