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Does angiotensin II or aldosterone regulate cyclooxygenase-2 expression in the kidney of male Sprague-Dawley rats?
Does angiotensin II or aldosterone regulate cyclooxygenase-2 expression in the kidney of male Sprague-Dawley rats?
Angiotensin II directly inhibits kidney cortex cyclooxygenase-2 protein expression in a rat model of hypertension, independent of aldosterone stimulation.
Preclinical rat data leave open human relevance of Ang II-specific renal COX-2 effects; no practice change indicated.
The renin-angiotensin cascade plays an important role in blood pressure control and sodium homeostasis. This study investigated whether cyclooxygenase-2 expression is regulated in the kidney, in an angiotensin II- and aldosterone-induced hypertension model. For this purpose, we treated male Sprague-Dawley rats (n=8 per group) with angiotensin II (9 mg/h, subcutaneously) for 14 d and aldosterone (0.75 mg/h, subcutaneously) for 42 d. Systolic blood pressure was significantly increased by angiotensin II (p<0.001) and by aldosterone (p<0.001). We found that angiotensin II downregulated cyclooxygenase-2 protein in the kidney cortex, whereas aldosterone showed no effect. These results indicate that angiotensin II may act directly to inhibit kidney cortex cyclooxygenase-2 protein expression, rather than acting via stimulation of aldosterone.
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Lim et al. (2003) studied this question.
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