COX-2 beneficially modulates Ang II effects on renal hemodynamics, except in the presence of inflammation promoted by hypertension, hyperglycemia, and oxidative stress.
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Context-dependent COX-2 effects on sodium excretion merit attention in RAS-active states; leaves open targeted interventions in inflamed hypertensive or diabetic kidneys.
Green et al. (2011) studied this question.
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