August 1, 2003Clinical ChemistryOpen Access

Utility of the Amino-Terminal Fragment of Pro-Brain Natriuretic Peptide in Plasma for the Evaluation of Cardiac Dysfunction in Elderly Patients in Primary Health Care

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Why the study?

Does plasma NT-proBNP measurement identify impaired cardiac function in elderly primary care patients with symptoms of heart failure?

Population

415 elderly patients presenting to a primary healthcare center with dyspnea, fatigue, and/or peripheral edema.

Comparison

Measurement of plasma N-terminal proBNP using an… vs Echocardiographic assessment of cardiac function

Design

Cross-sectional

Authors

UAUrban AlehagenLinköping University GLGöran LindstedtNational Institutes of Health HEHenry ErikssonVascular Medicine

Discussion

Member takes

Implication

May aid identification of impaired function in symptomatic elderly; leaves open whether NT-proBNP improves outcomes in primary care.

Structured PICO

Does plasma NT-proBNP measurement identify impaired cardiac function in elderly primary care patients with symptoms of heart failure?

Population

415 elderly patients (mean age 72 years, 221 men, 194 women) presenting to a primary healthcare center with dyspnea, fatigue, and/or peripheral edema.

Intervention

Measurement of plasma N-terminal proBNP (NT-proBNP) using an in-house RIA

Comparator

Echocardiographic assessment of cardiac function (systolic dysfunction defined as LVEF ≤40%, and diastolic dysfunction)

Outcome

Identification of impaired cardiac functionsurrogate

Plasma NT-proBNP is a useful biomarker for identifying systolic and specific types of diastolic dysfunction in elderly primary care patients presenting with heart failure symptoms.

Cite This Study

Alehagen et al. (2003) studied this question.

synapsesocial.com/papers/6a736273644e61a44f4e5957 https://doi.org/10.1373/49.8.1337

Topics

Heart failure HFrEF treatment Women and heart disease

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Utility of the Amino-Terminal Fragment of Pro-Brain Natriuretic Peptide in Plasma for the Evaluation of Cardiac Dysfunction in Elderly Patients in Primary Health Care

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Utility of the Amino-Terminal Fragment of Pro-Brain Natriuretic Peptide in Plasma for the Evaluation of Cardiac Dysfunction in Elderly Patients in Primary Health Care

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider