A proposed kinetic model of striated muscle contraction successfully fits experimental data and enables simulation of complex 3D muscle contractions.
Should not alter clinical practice; leaves open validation of 3D muscle models for cardiac research.
A simple kinetic model of muscle contraction is suggested. The rates of cross-bridge transitions from one kinetic state to another one are supposed to depend on the strain averaged over an ensemble of actin-bound bridges. With a proper set of strain-dependent rate constants, the model fits well a broad range of experimental data. Owing to that the strain-stress relation is described by a set of ordinary differential equations, the model can be used for simulating complex 3D muscle contractions.
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Syomin et al. (2012) studied this question.
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