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January 1, 2005Thrombosis and Haemostasis

Medical conditions increasing the risk of chronic thromboembolic pulmonary hypertension

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Why the study?

Do specific medical conditions increase the risk of developing chronic thromboembolic pulmonary hypertension compared to acute pulmonary embolism?

Population

296 patients, comprising 109 consecutive patients with chronic thromboembolic pulmonary hypertension and 187…

Comparison

Presence of specific medical conditions vs Absence of these specific medical conditions

Design

Case-control

Authors

DBDiana BondermanHeart Failure / CardiomyopathyJJJohannes JakowitschHeart Failure & TransplantCAChristopher AdlbrechtHeart Failure & Transplant

Discussion

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Implication

These associations may inform post-PE risk stratification; leaves open whether targeted surveillance or prevention alters CTEPH incidence.

Structured PICO

Do specific medical conditions increase the risk of developing chronic thromboembolic pulmonary hypertension compared to acute pulmonary embolism?

P
Population
296 patients, comprising 109 consecutive patients with chronic thromboembolic pulmonary hypertension (CTEPH) and 187 control patients with acute pulmonary embolism confirmed by a high probability lung scan.
I
Intervention
Presence of specific medical conditions (splenectomy, ventriculo-atrial shunt for hydrocephalus, or chronic inflammatory disorders such as osteomyelitis and inflammatory bowel disease)
C
Comparator
Absence of these specific medical conditions
O
Outcome
Diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH)

Splenectomy, ventriculo-atrial shunts, and chronic inflammatory disorders are strongly associated with an increased risk of developing chronic thromboembolic pulmonary hypertension.

Cite This Study

Bonderman et al. (2005) studied this question.

synapsesocial.com/papers/6a7367ad64decaab472c2ee2https://doi.org/10.1160/th04-10-0657

Topics

Pulmonary embolism
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Also Consider

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  1. 1Chronic Thromboembolic Pulmonary Hypertension — Not So Rare after All2004 · 253 citations
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