Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 2001American Journal of Respiratory and Critical Care Medicine

Plasma Monocyte Chemoattractant Protein-1 and Pulmonary Vascular Resistance in Chronic Thromboembolic Pulmonary Hypertension

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Is the severity of pulmonary hypertension (pulmonary vascular resistance) related to circulating levels of MCP-1 in patients with CTEPH?

Population

14 patients with chronic thromboembolic pulmonary hypertension (CTEPH)

Design

Cross-sectional

Authors

HKHiroshi KimuraFukushima Medical UniversityOOOsamu OkadaKyushu UniversityNTNobuhiro TanabeVascular / Pulmonary Vascular

Discussion

Loading...

Member takes

Implication

MCP-1 association with PVR in CTEPH is hypothesis-generating; should not yet change practice or guide targeted therapies.

Structured PICO

Is the severity of pulmonary hypertension (pulmonary vascular resistance) related to circulating levels of MCP-1 in patients with CTEPH?

P
Population
14 patients with chronic thromboembolic pulmonary hypertension (CTEPH)
I
Intervention
Measurement of circulating levels of Monocyte Chemoattractant Protein-1 (MCP-1), interleukin-1beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha)
O
Outcome
Correlation between plasma MCP-1 levels and pulmonary vascular resistancesurrogate

Plasma MCP-1 levels correlate with pulmonary vascular resistance in CTEPH, suggesting a role for MCP-1 in the inflammatory remodeling of pulmonary arteries.

Cite This Study

Kimura et al. (2001) studied this question.

synapsesocial.com/papers/6a7367ad64decaab472c2ee4https://doi.org/10.1164/ajrccm.164.2.2006154

Topics

Pulmonary embolism
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line.1989 · 771 citations
  2. 2Vesnarinone, a new inotropic agent, inhibits cytokine production by stimulated human blood from patients with heart failure.1994 · 156 citations
  3. 3Increased Expression of Interleukin-1β and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Hypertrophied and Failing Heart With Pressure Overload1997 · 163 citations
  4. 4Long-Term Outcome after Pulmonary Thromboendarterectomy1999 · 316 citations
  5. 5Neointimal macrophages colocalize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries.1993 · 62 citations