June 1, 1994Circulation
Expression of type 1 plasminogen activator inhibitor in chronic pulmonary thromboemboli.
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Discussion
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Implication
Histopathological study reveals elevated plasminogen activator inhibitor 1 in chronic pulmonary thromboemboli, suggesting a role in clot stabilization.
Key Points
- To determine whether persistent pulmonary thromboemboli fail to resolve due to localized expression of type 1 plasminogen activator inhibitor (PAI-1).
- Harvested chronic thromboembolic tissue specimens from patients undergoing pulmonary thromboendarterectomy (n = 16).
- Assessed PAI-1 and tissue-type plasminogen activator antigen and mRNA levels across fresh and organized thrombi using immunohistochemistry and in situ hybridization.
- Endothelial cells lining red, fibrin-rich thrombi exhibited strong PAI-1 antigen staining and significantly higher PAI-1 mRNA levels than endothelial cells from noninvolved arterial regions (n = 16, P < .001), while tissue-type plasminogen activator levels remained low.
- Organized yellowish-white thrombi containing smooth muscle cells and endothelial cells displayed marked PAI-1 antigen expression and elevated PAI-1 mRNA compared to thrombus-free arterial tissue (n = 16, P < .02).
Cite This Study
Lang et al. (1994) studied this question.