September 17, 2011DiabetesOpen Access

APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

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Population

APPL1 knockout mice, APPL1 transgenic mice, and endothelial cells

Comparison

Genetic manipulation of APPL1 vs Wild-type/control mice and cells

Design

Preclinical

Authors

YWYi WangShanghai Medical College of Fudan University KCKenneth K.Y. ChengHong Kong Polytechnic University KLKaren S.L. LamUniversity of Hong Kong

Discussion

Member takes

Implication

APPL1 regulates insulin vascular effects in obese mice; hypothesis-generating for endothelial insulin resistance but should not yet change practice.

Structured PICO

Population

APPL1 knockout mice, APPL1 transgenic mice, and endothelial cells (including 8-week-old mice, ageing models, and high-fat diet-induced obesity models)

Intervention

Genetic manipulation of APPL1 (transgenic expression or knockout)

Comparator

Wild-type/control mice and cells

Outcome

Vascular reactivity (insulin-induced vasodilation and vasoconstriction) and molecular signaling (Akt, ERK1/2, NO, ET-1)surrogate

APPL1 plays a key role in coordinating the vasodilator and vasoconstrictor effects of insulin in the endothelium, suggesting a potential target for obesity-induced vascular insulin resistance.

Cite This Study

Wang et al. (2011) studied this question.

synapsesocial.com/papers/6a736b118317ef39e84e5b8d https://doi.org/10.2337/db11-0666

View Full Paper

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Implication

APPL1 regulates insulin vascular effects in obese mice; hypothesis-generating for endothelial insulin resistance but should not yet change practice.

APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider