January 31, 2003Annual Review of Physiology
Stress-Activated Cytokines and The Heart: From Adaptation to Maladaptation
Key Points
- This review explores how the myocardium responds to environmental stress through cytokine expression and its implications for heart function.
- Reviewed recent experimental findings on cytokines in the myocardium under stress.
- Focused on the roles of TNF, IL-1, and IL-6 family in heart adaptation and maladaptation.
- Analyzed the balance between short-term adaptation and long-term maladaptation in cardiac responses.
- Short-term expression of cytokines is adaptive, promoting homeostasis under stress.
- Prolonged cytokine expression can lead to cardiac decompensation.
- High concentrations of these cytokines may trigger heart failure.
Design
Review
Authors
Discussion
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Implication
Supports biphasic cytokine effects in stressed myocardium; leaves open whether targeted modulation alters HF progression.
Cite This Study
Douglas L. Mann (2003) studied this question.