Why the study?
Does postoperative NSAID use reduce the incidence of post-cardiothoracic surgery atrial fibrillation without increasing the risk of stroke or MI?
Population
555 patients undergoing cardiothoracic surgery from the Atrial Fibrillation Suppression Trials I, II and…
Comparison
Postoperative nonsteroidal anti-inflammatory… vs No postoperative NSAID use
Design
Cohort
Authors
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Post-CTS NSAID use merits randomized evaluation for AF prevention; leaves stroke/MI risks unresolved.
Does postoperative NSAID use reduce the incidence of post-cardiothoracic surgery atrial fibrillation without increasing the risk of stroke or MI?
Postoperative NSAID use in cardiothoracic surgery patients is associated with a reduced risk of postoperative atrial fibrillation and RBC transfusions, though safety regarding stroke and MI requires further adequately powered studies.
Ruffin et al. (2008) studied this question.
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