Why the study?
Does colchicine improve active tension and passive stiffness in isolated left ventricular papillary muscles from rats with heart failure?
Population
18- to 24-month-old spontaneously hypertensive rats with heart failure, age-matched SHR without heart…
Comparison
Colchicine (10, 10, and 10 mol/L) exposure for… vs Baseline state before colchicine exposure
Design
Preclinical
Follow-up
up to 90 minutes
Authors
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Colchicine shows no benefit on rat HF myocardial mechanics; leaves open effects in other models or translation to humans.
Does colchicine improve active tension and passive stiffness in isolated left ventricular papillary muscles from rats with heart failure?
Colchicine does not improve intrinsic muscle function in hypertrophied or failing left ventricular myocardium in a rat model.
Cicogna et al. (1999) studied this question.
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