What question did this study set out to answer?

October 1, 2000Obesity Research

The Activity of the Hypothalamic‐Pituitary‐Adrenal Axis and the Sympathetic Nervous System in Relation to Waist/Hip Circumference Ratio in Men

View Full Paper

Ask AI

Bookmark

Why the study?

Does a high waist/hip circumference ratio correlate with altered HPA axis and sympathetic nervous system activity in non-diabetic, middle-aged men?

Population

50 non-diabetic, middle-aged men selected to obtain two groups with similar body mass index but different…

Comparison

High waist/hip circumference ratio (WHR) vs Low waist/hip circumference ratio (WHR)

Design

Cross-sectional

Authors

TLThomas LjungMälardalen University GHGöran HolmLuleå University of Technology PFPeter FribergPreventive Cardiology

Discussion

Member takes

Implication

High WHR may mark HPA/sympathetic dysregulation beyond BMI; hypothesis-generating for cardiometabolic risk, needs prospective confirmation.

Key Points

To determine whether men with abdominal obesity differ in the activity and regulation of the hypothalamic-pituitary-adrenal axis and sympathetic nervous system compared to men with general obesity.
Evaluated 50 non-diabetic, middle-aged men matched for body mass index (BMI) but divided into groups with high versus low waist/hip circumference ratio (WHR).
Measured basal and post-oral glucose tolerance test metabolic markers, diurnal ACTH, cortisol, and growth hormone profiles, urinary catecholamine metabolites, and responses to CRH and laboratory stress.
Men with high WHR had significantly higher basal glucose, insulin, and triglycerides, as well as higher post-load glucose and insulin concentrations, compared to men with low WHR.
High-WHR men showed elevated diurnal ACTH, reduced growth hormone peak size, and blunted cortisol levels in the morning and following CRH or stress challenges.
High WHR was associated with elevated basal and post-challenge pulse pressure and heart rate, alongside increased urinary excretion of catecholamine metabolites.

Structured PICO

Does a high waist/hip circumference ratio correlate with altered HPA axis and sympathetic nervous system activity in non-diabetic, middle-aged men?

Population

50 non-diabetic, middle-aged men selected to obtain two groups with similar body mass index (BMI) but different waist/hip circumference ratio (WHR)

Intervention

High waist/hip circumference ratio (WHR)

Comparator

Low waist/hip circumference ratio (WHR)

Outcome

Activity and regulation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous systemsurrogate

Abdominal obesity (high WHR) is associated with mild dysregulation of the HPA axis and central activation of the sympathetic nervous system independent of BMI.

Cite This Study

Ljung et al. (2000) studied this question.

synapsesocial.com/papers/6a736e706cf7a6ca1f6c3538 https://doi.org/10.1038/oby.2000.61

View Full Paper

Ask AI

Bookmark

Implication

High WHR may mark HPA/sympathetic dysregulation beyond BMI; hypothesis-generating for cardiometabolic risk, needs prospective confirmation.

The Activity of the Hypothalamic‐Pituitary‐Adrenal Axis and the Sympathetic Nervous System in Relation to Waist/Hip Circumference Ratio in Men

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The Activity of the Hypothalamic‐Pituitary‐Adrenal Axis and the Sympathetic Nervous System in Relation to Waist/Hip Circumference Ratio in Men

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider