January 4, 2017European Heart JournalOpen Access

Inverse remodelling of K2P3.1 K⁺channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy

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Structured PICO

Population

175 patients exhibiting different stages of left ventricular (LV) dysfunction, including individuals in sinus rhythm, paroxysmal atrial fibrillation, and chronic atrial fibrillation.

Comparator

Patients with preserved LV function and different heart rhythms (sinus rhythm vs. paroxysmal AF vs. chronic AF)

Outcome

Atrial K2P3.1 K+ channel expression (quantified by real-time PCR and Western blot) and action potential duration (APD)surrogate

Differential remodeling of atrial K2P3.1 channels in the presence of LV dysfunction and chronic AF highlights a specific electrical substrate that could serve as a target for personalized antiarrhythmic therapy.

Discussion

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Implication

May inform patient-specific AF therapy in LV dysfunction; leaves open need for clinical validation of K2P3.1 targeting.

Cite This Study

Schmidt et al. (2017) studied this question.

synapsesocial.com/papers/6a7372c961762fa209a7291e https://doi.org/10.1093/eurheartj/ehw559

Topics

Persistent AF management Atrial fibrillation Anticoagulation in AF AF ablation outcomes

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Inverse remodelling of K2P3.1 K⁺channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy

Structured PICO

Discussion

Implication

Cite This Study

Topics

Inverse remodelling of K2P3.1 K⁺channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider