July 15, 2004Proceedings of the National Academy of SciencesOpen Access

A point mutation in the regulatory light chain reduces the step size of skeletal muscle myosin

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Population

Skeletal muscle myosin

Comparison

Single-point mutation in the skeletal myosin… vs Wild-type skeletal myosin (implied)

Design

Preclinical

Authors

JSJennifer J. SherwoodPublic Policy Institute of California GWGuillermina S. WallerUniversity of Vermont DWDavid M. WarshawUniversity of Vermont

Discussion

Member takes

Implication

Hypothesis-generating in animal models; leaves open light chain isoform effects on human myosin mechanics.

Structured PICO

Population

Skeletal muscle myosin

Intervention

Single-point mutation in the skeletal myosin regulatory light chain (RLC)

Comparator

Wild-type skeletal myosin (implied)

Outcome

Actin filament velocity (V(actin)) and unitary displacement (step size, d)surrogate

A single-point mutation in the regulatory light chain of skeletal myosin reduces its step size and actin filament velocity, suggesting light chain isoforms modulate flexural rigidity to maximize tension and movement.

Cite This Study

Sherwood et al. (2004) studied this question.

synapsesocial.com/papers/6a7372e720644e164b4e5b81 https://doi.org/10.1073/pnas.0401699101

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A point mutation in the regulatory light chain reduces the step size of skeletal muscle myosin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A point mutation in the regulatory light chain reduces the step size of skeletal muscle myosin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider