March 15, 1994The Journal of Cell BiologyOpen Access

Coupling of ATPase activity and motility in smooth muscle myosin is mediated by the regulatory light chain

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Population

Smooth muscle myosin

Comparison

Removal or truncation of the regulatory light… vs Native phosphorylated myosin and…

Design

Preclinical

Authors

KTKM TrybusBrandeis University GWGS WallerUniversity of Vermont TCT.A. ChatmanBrandeis University

Discussion

Member takes

Implication

C-terminal RLC residues modulate smooth muscle myosin; leaves open therapeutic targeting in vascular disease.

Structured PICO

Population

Smooth muscle myosin

Intervention

Removal or truncation of the regulatory light chain (RLC) (truncating 6, 12, or 26 residues from the COOH terminus, or using only the COOH-terminal RLC domain)

Comparator

Native phosphorylated myosin and dephosphorylated myosin

Outcome

Myosin motility (velocity) and ATPase activitysurrogate

The COOH-terminal portion of the regulatory light chain is crucial for regulating the 'on-off' switch of smooth muscle myosin motility and ATPase activity.

Cite This Study

Trybus et al. (1994) studied this question.

synapsesocial.com/papers/6a7372e820644e164b4e5b8a https://doi.org/10.1083/jcb.124.6.963

View Full Paper

Ask AI

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Coupling of ATPase activity and motility in smooth muscle myosin is mediated by the regulatory light chain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Coupling of ATPase activity and motility in smooth muscle myosin is mediated by the regulatory light chain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider