Population
Dictyostelium regulatory light chain (RLC) null mutant model
Comparison
Expression of three RLC point mutations… vs Wild-type Dictyostelium myosin and RLC null mutant
Design
Preclinical
Authors
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No immediate implications for FHC management; leaves open whether RLC mutations drive human disease via myosin kinetics.
RLC point mutations corresponding to human familial hypertrophic cardiomyopathy directly impair myosin force transmission and kinetic properties in a Dictyostelium model.
Chaudoir et al. (1999) studied this question.
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