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This study aims to identify the specific molecular form of (Na+ + K+)-ATPase inhibited by pyrithiamin.

Specific inactivation of alpha (+) molecular form of (Na+ + K+)-ATPase by pyrithiamin.

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This study aims to identify the specific molecular form of (Na+ + K+)-ATPase inhibited by pyrithiamin.
Conducted sodium dodecyl sulfate-polyacrylamide gel electrophoresis to analyze enzyme phosphorylation.
Examined enzyme sensitivity changes in the presence of pyrithiamin and other agents.
Investigated various (Na+ + K+)-ATPases from developing rat brain and peripheral tissues.
Pyrithiamin decreased phosphorylation of alpha (+) in a dose-dependent manner (p<0.05).
Pyrithiamin minimally inhibited alpha molecular forms in peripheral tissues except dog cardiac tissues.
The alpha (+) form was predominant in rat brain postnatal stages, revealing development-related selectivity.

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Experimental examination of pyrithiamin's impact on Na+ + K+-ATPase forms in rat brain, suggesting selective inhibition effects.

Matsuda et al. (1984) studied this question.

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