Key result
Hypothyroidism in 15-day-old rats decreased the abundance of brain Na+-K+-ATPase alpha+ and alpha subunits to 69% and 48% of control values, respectively.
Both alpha and alpha+ subunits of Na+-K+-ATPase increase in the brain during pre- and neonatal development and are regulated by thyroid hormones.
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May affect neonatal brain ion homeostasis in hypothyroidism; extends developmental regulation evidence but leaves open human translation.
Schmitt et al. (1986) studied this question. Hypothyroidism vs. Control was evaluated on Abundance of alpha and alpha+ subunits of Na+-K+-ATPase. Hypothyroidism in 15-day-old rats decreased the abundance of brain Na+-K+-ATPase alpha+ and alpha subunits to 69% and 48% of control values, respectively.
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