Population
AT1 angiotensin receptor (wild-type and N111G mutant)
Design
Preclinical
Authors
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Does not alter ARB use; leaves open translation while challenging conformational selection models of AT1 activation.
Angiotensin II actively induces the active state of the AT1 receptor rather than merely selecting a spontaneously generated active conformation.
Noda et al. (1996) studied this question.
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