Population
Human AT1 receptor expressing CHO-K1 cells (wild-type and mutants including N111G and D281A)
Comparison
Angiotensin IV and other angiotensin peptides… vs Wild-type AT1 receptors vs mutant AT1 receptors
Design
Preclinical
Authors
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N111G mutation boosts Ang IV potency at AT1; leaves open whether this informs human receptor-targeted therapies.
The N111G mutation in the human AT1 receptor causes a conformational change that significantly increases the potency and affinity of Angiotensin IV, providing insight into the mechanism of receptor activation.
Lê et al. (2002) studied this question.
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