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January 1, 2021Annals of Translational MedicineOpen Access

Treatment of venous thromboembolism in cancer patients: a systematic review and meta-analysis on the efficacy and safety of different direct oral anticoagulants (DOACs)

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Why the study?

The study was conducted to evaluate the efficacy and safety of different direct oral anticoagulants compared with low molecular weight heparins for treating venous thromboembolism in cancer patients.

Do DOACs reduce VTE recurrence compared to LMWHs in cancer patients with VTE?

Population

Cancer patients with VTE across 18 eligible studies (4 RCTs and 14 retrospective studies)

Comparison

DOACs vs LMWHs

Design

Systematic review and meta-analysis

Authors

XSXiaojun SongZLZhili LiuRZRong Zeng

Discussion

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Member takes

Overview

DOACs reduce recurrent VTE/DVT versus LMWH in cancer; reinforces first-line preference in guidelines.

Structured PICO

Do DOACs reduce VTE recurrence compared to LMWHs in cancer patients with VTE?

P
Population
Cancer patients with venous thromboembolism (VTE) from 18 articles (4 RCTs and 14 retrospective studies)
I
Intervention
Direct oral anticoagulants (DOACs)
C
Comparator
Low molecular weight heparins (LMWHs)
O
Outcome
Venous thromboembolism (VTE) recurrencehard clinical

DOACs are more effective than LMWHs in preventing VTE and DVT recurrence in cancer patients, though they are associated with an increased risk of clinically relevant non-major bleeding.

Cite This Study

Song et al. (2021) studied this question.

synapsesocial.com/papers/6a737d22007d73ca2ffb6600https://doi.org/10.21037/atm-20-8156
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessment of venous thromboembolism treatment in patients with cancer on low molecular weight heparin, warfarin, and the direct oral anticoagulants2017 · 17 citations
  2. 2Effectiveness and safety of anticoagulants for the treatment of venous thromboembolism in patients with cancer2018 · 96 citations
  3. 3A single center retrospective cohort study comparing low-molecular-weight heparins to direct oral anticoagulants for the treatment of venous thromboembolism in patients with cancer – A real world experience2018 · 17 citations
  4. 4A Retrospective Study on Efficacy and Safety of Rivaroxaban and Dalteparin for Long-Term Treatment of Venous Thromboembolism in Patients with Lung Cancer2019 · 24 citations
  5. 5Retrospective comparison of low molecular weight heparin vs. warfarin vs. oral Xa inhibitors for the prevention of recurrent venous thromboembolism in oncology patients: The Re-CLOT study2017 · 31 citations