Answers are grounded in this paper and cite their sources.
Structure-activity relationship studies on CXCR4 antagonists, which were previously found by using cyclic pentapeptide libraries, were performed to optimize side-chain functional groups, involving conformationally constrained analogues. In addition, a new lead of cyclic pentapeptides with the introduction of a novel pharmacophore was developed.
No takes yet. Share an insight, caveat, or question.
Tamamura et al. (2005) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: