In elderly patients with arterial hypertension, carotid intima-media thickening is associated with pulse pressure, reduced superoxide dismutase activity, and lower oxidative resistance of LDLs.
Should not yet change hypertension management in the elderly; leaves open whether SOD activity or LDL resistance causally influence pulse pressure-related carotid thickening.
To determine the specifics of peroxide homeostasis, which depends on the intensity of atherosclerotic affection of the common carotid artery (CCA), 75 patients aged 60–74 with arterial hypertension (AH) (the average age was 64.62 ± 0.57 years) and 30 nearly healthy elderly people were examined. The thickness of the intima-media complex (IMC) of the CCA was measured, as well as the existence of atherosclerotic plaques. The characteristics of the lipid blood spectrum, LPO, and the antioxidant system (catalase, SOD, and overall antioxidant blood serum activity) were evaluated. An increase in the value of the IMC within a range of 0.9–1.3 mm was influenced by a decrease in the oxidizing potential of LDLs and the activation of LPO. According to the results of a multiple step-by-step regression analysis it was found that the thickening of the IMC of the CCA was associated with pulse pressure. The variability of structural changes in the form of atherosclerotic affection of the CCA alongside AH depended on age, SOD activity, and oxidative resistance of LDLs.
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Горшунова et al. (2012) studied this question.
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