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Papillary muscle inactivation rarely causes severe or persistent mitral incompetence in dogs; leaves open its role in human mitral regurgitation.
The effect of papillary muscle inactivation on mitral valve competence has been studied in 28 dogs for up to six months. Ten animals showed evidence of mitral incompetence at some stage. In only two was severe incompetence produced, and one of these animals died after 20 days. In five of the 10 animals mitral incompetence regressed in the follow-up period. Fibrotic or calcific lesions were found in the mitral valves of five animals, but in only three were these gross.
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Taylor et al. (1970) studied this question.
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