New N-methyl and N-ethyl substitutions in the indazole nucleus are reported by reacting 3-(2aminobenzamido)indazole and the appropriate trimethyl/triethyl orthobenzoate. Single crystal Xray analysis confirms the N-ethylation position for the 3-(1-ethyl-1H-indazol-3-yl)-2phenylquinazolin-4(3H)-one derivative 3f. Compounds 11a-d and 3a-d were tested to evaluate their antimicrobial, antiproliferative and COX inhibitory activities, showing scarce or moderately antiproliferative activity and some inhibitory activity against COX-1 and COX-2.
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Plescia et al. (2010) studied this question.
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