Why the study?
Understanding how certain animals regenerate their hearts may provide insights into inducing regeneration in humans to reverse myocardial infarction damage, but how interstitial cells behave during this process is unclear.
This study identifies key differences in the fibrotic response between zebrafish and mammals and highlights the roles of tal1 in endothelial cells and mmp14 in macrophages during cardiac regeneration.
Hypothesis-generating for interstitial cell roles in regeneration; leaves open translation to human post-MI repair.
Understanding how certain animals are capable of regenerating their hearts will provide much needed insights into how this process can be induced in humans in order to reverse the damage caused by myocardial infarction. Currently, it is becoming increasingly evident that cardiac interstitial cells play crucial roles during cardiac regeneration. To understand how interstitial cells behave during cardiac regeneration, we performed single-cell RNA sequencing (scRNA-seq) of regenerating zebrafish hearts. Using a combination of immunohistochemistry, chemical inhibition and novel transgenic animals, we were able to investigate the role of cell type specific responses during cardiac regeneration. This approach allowed us to identify a number of important regenerative mechanisms within the interstitial cell populations. Here, we provide here a detailed insight into how interstitial cells behave during cardiac regeneration and identify a number of novel features of these cells which will serve to increase our understanding of how this process could eventually be induced in humans.
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Rolland et al. (2021) studied this question.
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