What question did this study set out to answer?

Summarize the synergistic mechanisms by which natural products modulate redox signalling pathways to improve anticancer drug sensitivity and reduce treatment-related adverse effects.

August 20, 2024Chinese MedicineOpen Access

Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balance

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Authors

YSYitian SunNorth China University of Technology QLQinyi LiGriffith University YHYufei HuangHangzhou Normal University

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Implication

Review reveals natural products enhance therapeutic sensitivity and mitigate chemotherapy toxicity through redox modulation in cancer models, suggesting promising strategies for combination...

Key Points

Summarize the synergistic mechanisms by which natural products modulate redox signalling pathways to improve anticancer drug sensitivity and reduce treatment-related adverse effects.
Synthesized preclinical and clinical literature evaluating natural products administered as monotherapies or adjuvants with conventional chemotherapeutic agents.
Analyzed the molecular pathways through which bioactive compounds manipulate oxidative stress and redox homeostasis in drug-resistant tumours.
Natural products modulate redox balance to induce cytotoxic oxidative damage in malignant cells while shielding normal tissues from chemotherapy toxicity.
Multiple natural product-derived adjuvant formulations have shown efficacy in overcoming anticancer drug resistance and have progressed into clinical trials.

Cite This Study

Sun et al. (2024) studied this question.

synapsesocial.com/papers/6a7394ff8317ef39e84e66af https://doi.org/10.1186/s13020-024-00982-2

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Implication

Review reveals natural products enhance therapeutic sensitivity and mitigate chemotherapy toxicity through redox modulation in cancer models, suggesting promising strategies for combination...

Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balance

Discussion

Member takes

Implication

Key Points

Cite This Study

Natural products for enhancing the sensitivity or decreasing the adverse effects of anticancer drugs through regulating the redox balance

Discussion

Member takes

Implication

Key Points

Cite This Study

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