Leptin is Associated with Endothelial Dysfunction in Healthy Obese Premenopausal Women

Kihwan Kwon; Kyungsun Choi; Si-Hoon Park

doi:10.4070/kcj.2007.37.6.251

January 1, 2007Sunhwan'giOpen Access

Leptin is Associated with Endothelial Dysfunction in Healthy Obese Premenopausal Women

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Why the study?

Is elevated plasma leptin associated with impaired endothelium-dependent vasodilation in healthy obese premenopausal women?

Structured PICO

Is elevated plasma leptin associated with impaired endothelium-dependent vasodilation in healthy obese premenopausal women?

P

Population

60 healthy premenopausal women (37 obese with BMI ≥25 kg/m², 23 age-matched non-obese with BMI <25 kg/m²) aged 20-45 years, free of acute or chronic diseases (hypertension, dyslipidemia, type II diabetes, coronary heart disease, stroke, thyroid disease, depression) and non-smokers.

I

Intervention

Obesity and elevated plasma leptin concentrations

C

Comparator

Non-obese healthy premenopausal women (BMI <25 kg/m²)

O

Outcome

Endothelium-dependent vasodilation measured by noninvasive pulse wave analysis coupled with provocative pharmacological testing with salbutamol (ΔAIx(Salbutamol, %))surrogate

Increased plasma leptin concentration is independently associated with impaired endothelial function in healthy obese premenopausal women, suggesting a potential mechanism linking obesity to early atherosclerosis.

Limitations

Small sample size
Cross-sectional design cannot prove a causal association between leptin concentration and vascular dysfunction
BMI was used to evaluate obesity without measuring waist-hip ratio or percent body fat

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Answers are grounded in this paper and cite their sources.

Implication

May link leptin to endothelial impairment in obese women; hypothesis-generating and should not yet change practice.

Discussion

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Cite This Study

Kwon et al. (2007) studied this question.

synapsesocial.com/papers/6a739516ac21afd3a771b6ee https://doi.org/10.4070/kcj.2007.37.6.251

View Full Paper

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Leptin is Associated with Endothelial Dysfunction in Healthy Obese Premenopausal Women

Structured PICO

Limitations

Ask about this paper

Implication

Discussion

Cite This Study

Leptin is Associated with Endothelial Dysfunction in Healthy Obese Premenopausal Women

Structured PICO

Limitations

Ask about this paper

Implication

Discussion

Cite This Study

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