Why the study?
Does ex vivo leptin induce vasorelaxation in vessels from patients with coronary artery disease?
Population
131 patients with coronary artery disease, mean age 65.7+/-0.7 years
Comparison
Ex vivo exposure to leptin (10(-13)-10(-7) M) vs Control conditions, L-NMMA, endothelial…
Design
Preclinical
Authors
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Hypothesis-generating for leptin's vascular effects in CAD; leaves open any in vivo or clinical relevance.
Does ex vivo leptin induce vasorelaxation in vessels from patients with coronary artery disease?
Leptin acts as an endothelium-independent vasodilator in human vessels via smooth muscle hyperpolarization, and its effects do not correlate with markers of body fat, suggesting tissue-specific leptin resistance.
Aziz Momin (2006) studied this question.
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